Viravaxx’ lead product is VVX001, a clinical phase II vaccine candidate for Hepatitis B. VVX001 is a recombinant fusion protein composed of PreS from the large surface antigen of HBV and synthetic peptides. Viravaxx recently delivered interim results on VVX001 that support the hope for a new Hepatitis B vaccine. For more information concerning the trial design and background publications go to ClinicalTrials.gov (NCT03625934).
VVX001 triggers an immune response which blocks the virus from binding to NTCP. This blocking activity inhibits virus entry.
VVX001 is currently in a clinical phase II trial conducted in low-/non-responders as well as in chronically infected Hepatitis B patients.
Respiratory Syncytial Virus
As a result of research funded by Viravaxx and the Austrian Science Fund (FWF), the Valenta Labs currently investigate several RSV candidate vaccine constructs in immunological testing experiments. Contact Viravaxx for business development inquiries at firstname.lastname@example.org.
- Borochova K, Niespodziana K, Focke-Tejkl M, Hofer G, Keller W, Valenta R. Dissociation of the respiratory syncytial virus F protein-specific human IgG, IgA and IgM response. Scientific Reports (2021). Vol 11, 3551; https://www.nature.com/articles/s41598-021-82893-y.
- Borochova K, Niespodziana K, Stenberg Hammar K, van Hage M, Hedlin G, Söderhäll C, Focke-Tejkl M, Valenta R. Features of the Human Antibody Response against Respiratory Syncytial Virus Surface Glycoprotein G. Vaccines (2020). 8(2):337; https://doi.org/10.3390/vaccines8020337.
As a result of research funded by Viravaxx, the Valenta Labs recently succeeded in defining binding sites for human rhinovirus by use of neutralizing antisera. Viravaxx is open to discuss its intellectual property base with interested companies. Contact Viravaxx for business development inquiries at email@example.com.
- Pazderova P, Waltl EE, Niederberger-Leppin V, Flicker S, Valenta R, Niespodziana K. ELISA-Based Assay for Studying Major and Minor Group Rhinovirus-Receptor Interactions. Vaccines (2020). 8(2): 315; https://doi.org/10.3390/vaccines8020315.
- Sam Narean J, Glanville N, Nunn CM, Niespodziana K, Valenta R, Johnston SL, McLean GR. Epitope mapping of antibodies induced with a conserved rhinovirus protein generating protective anti-rhinovirus immunity. Vaccine (2019). 37(21): 2805-2813; https://doi.org/10.1016/j.vaccine.2019.04.018.
- Gattinger P, Borochova K, Dorofeeva Y, Henning R, Kiss R, Kratzer B, Mühl B, Perkmann T, Trapin D, Trella M, Ettel P, Tulaeva I, Pickl W, Valenta R. Antibodies in serum of convalescent patients following mild COVID‐19 do not always prevent virus‐receptor binding. Allergy (2020). 00:1-6; https://doi.org/10.1111/all.14523.